Kitagawa K
[Current topics in stroke research] [English Abstract, Journal Article]
Nippon Rinsho 2009 Oct; 67(10):2003-11.
This review summarizes current topics for brain protection against stroke. Although there has been no strategy for brain protection except for tissue plasminogen activator, recent advance in neuroscience has addressed subtypes of glutamate receptor on neuronal survival and death. Hypothermia and ischemic tolerance are the most reproducible strategies for brain protection in experimental ischemia, and they share metabolic down-regulation as a crucial factor for protective action. Development of collateral circulation (arteriogenesis), endogenous neurogenesis after ischemia, gene therapy and cell transplantation are all potential targets for developing a new strategy for stroke patients.
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